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ABSTRACT

Simple HPLC Method for Simultaneous Estimation of Risperidone and Trihexyphenidyl HCl in Combined Dose Tablet

Dhaval S. Patel, Jaydeep M. Patel

ABSTRACT

A rapid and sensitive reverse phase high performance liquid chromatographic method is developed for simultaneous estimation of Risperidone and Trihexyphenidyl HCl in combine dose tablet. Chromatographic condition was on X bridge C18 column using phosphate buffer :Acetonitrile 0.5 ml TEA, 4.5 ± 0.5 pH adjusted by using 0.1N HCl (70:30%) as the mobile phase at a flow rate 0.8 ml/min with detection at 210nm.total run time of less then 20 min. the calibration curve were liner in the range 3-9µg/ml for Risperidone and 2-6 µg/ml for Trihexyphenidyl HCl. The method validated with respect to linearity, precision, accuracy and specificity. The mean recovery for Risperidone and Trihexyphenidyl HCl is 100.14±0.107 and 99.86±0.211, respectively. The utility of procedure is verified by application to the market formulation that was subjected tovarious stress condition. The method separated the two target drug. No chromatographic interference is observed. Keywords :Risperidone, Trihexyphenidyl hydrochloride, Validation, RP-HPLC.

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